Differential acute and chronic effects of burn trauma on murine skeletal muscle bioenergetics
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- 作者：Craig Portera ; b ; cr2porte@utmb.edu" class="auth_mail" title="E-mail the corresponding author ; David N. Herndona ; b ; Nisha Bhattaraia ; b ; John O. Ogunbilejea ; b ; Bartosz Szczesnyc ; Csaba Szaboc ; Tracy Toliver-Kinskyc ; Labros S. Sidossisa ; d
- 关键词：Burn ; Skeletal muscle ; Mitochondria ; Apoptosis ; Hypermetabolism
- 刊名：Burns
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：42
- 期：1
- 页码：112-122
- 全文大小：1288 K
文摘
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Burn results in skeletal muscle mitochondrial dysfunction.
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Mitochondria local to wounds exhibit and apoptotic phenotype acutely post burn.
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Mitochondria distal to wounds undergo a chronic loss of respiratory capacity and function.
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Locality to burn wounds dictates the timing and mode of muscle mitochondrial dysfunction.