- 作者：Alison M. Stuebe ; MD ; MSca ; astuebe@med.unc.edu ; Mark B. Landon ; MDb ; Yinglei Lai ; PhDp ; Catherine Y. Spong ; MDq ; Marshall W. Carpenter ; MDc ; Susan M. Ramin ; MDd ; Brian Casey ; MDe ; Ronald J. Wapner ; MDf ; Michael W. Varner ; MDg ; Dwight J. Rouse ; MDh ; Anthony Sciscione ; DOi ; Patrick Catalano ; MDj ; Margaret Harper ; MD ; MSck ; George Saade ; MDl ; Yoram Sorokin ; MDm ; Alan M. Peaceman ; MDn ; Jorge E. Tolosa ; MD ; MSCEo ; Eunice Kennedy Shriver National Institute of Child Health ; Human Development Maternal&ndash ; Fetal Medicine Units Network ; Bethesda ; MD
- 关键词：body mass index ; gestational diabetes mellitus (GDM) ; glycemia ; obesity
- 刊名：American Journal of Obstetrics and Gynecology
- 出版年：2012
- 出版时间：July, 2012
- 年：2012
- 卷：207
- 期：1
- 页码：62.e1-62.e7
- 全文大小：344 K
Objective
The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome.Study Design
In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity.
Results
Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass.
Conclusion
Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.