Influence of substituted groups on the binding ability of benzoyl-modified ;2;

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• 作者：Cao Yujuan ; Lu Runhua
• 关键词：;2 ; -Cyclodextrin derivatives ; Substituent effect ; Fluorescence spectroscopy ; TNS
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2009
• 出版时间：November 2009
• 年：2009
• 卷：74
• 期：4
• 页码：892-895
• 全文大小：247 K

文摘

A series of substituted benzoyl modified ;2;-cyclodextrins, including mono-6-O-(p-methylbenzoyl)-;2;-CD (1), mono-6-O-(m-methylbenzoyl)-;2;-CD (2), mono-6-O-(o-methylbenzoyl)-;2;-CD (3), mono-6-O-(p-methoxylbenzoyl)-;2;-CD (4), mono-6-O-(m-methoxylbenzoyl)-;2;-CD (5), mono-6-O-(o-methoxylbenzoyl)-;2;-CD (6), mono-6-O-(m, p-dimethoxylbenzoyl)]-;2;-CD (7), mono-6-O-(o,m-dimethoxylbenzoyl)-;2;-CD (8), and mono-(6-O-benzoyl)-;2;-CD (9) were synthesized and their inclusion properties were studied by using fluorescence spectroscopy. The binding constants (K_a) of the modified ;2;-CD derivatives with 2-p-toluidinylnaphthalene-6-sulfonate (TNS) were determined on the basis of the fluorescence spectroscopy. The effect of types and location of substituted groups of the benzene ring of the modified ;2;-cyclodextrins on the binding property was discussed. Results indicated that the substituents had significant influences on the binding abilities of modified ;2;-cyclodextrins.