The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster

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• 作者：Shobana Subramanian^a ; William K. Gottschalk^a ; So Young Kim^c ; Allen D. Roses^a ; ^b ; Ornit Chiba-Falek^a ; ^c ; ^{o.chibafalek@duke.edu}
• 关键词：PPARγ ; Chromosome 19q13.32 ; TOMM40 ; APOE ; APOC1 ; Transcription
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1863
• 期：3
• 页码：810-816
• 全文大小：708 K
• 卷排序：1863

文摘

Chromosome 19q13.32 is a gene rich region that contains the TOMM40-APOE-APOC1 genes and implicated in multiple phenotypes. This region exhibits a complex regulation and is enriched in potential PPARγ binding sites. γ knockdown resulted in increased levels of TOMM40, APOE and APOC1 –mRNAs, showing the strongest impact on APOE-mRNA. Low doses of PPARγ agonists decreased the levels of the TOMM40, APOE and APOC1-mRNAs, with the greatest effect on APOE-mRNA.