Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms
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- 作者：Silvia Cetrulloa ; 1 ; Stefania D'Adamoa ; b ; 1 ; Serena Guidottib ; c ; Rosa Maria Borzì ; c ; Flavio Flamignia ; flavio.flamigni@unibo.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPK ; AMP-activated protein kinase ; ECM ; extra-cellular matrix ; GROα ; growth-related oncogene α ; HT ; hydroxytyrosol ; LC3 ; microtubule-associated protein 1 light chain 3 ; MDC ; monodansylcadaverine ; OA ; osteoarthritis ; qRT-PCR ; quantitative RT-PCR ; ROS ; reactive oxygen species ; siRNA ; short interfering RNA ; SIRT-1 ; sirtuin 1 ; TOM20 ; translocase of outer mitochondrial membrane
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1181-1191
- 全文大小：1446 K
文摘
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Hydroxytyrosol protects chondrocytes from H2O2-induced DNA damage and cell death.
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Hydroxytyrosol induces autophagy activation.
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Autophagy mediates hydroxytyrosol protective action under oxidative stress.
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Hydroxytyrosol stimulates autophagy by SIRT1-dependent and -independent mechanisms.