Splenectomy following MCAO inhibits the TLR4-NF-κB signaling pathway and protects the brain from neurodegeneration in rats
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- 作者：Victor Fabrice Belinga ; 1 ; belfabrizio2005@yahoo.fr" class="auth_mail" title="E-mail the corresponding author ; Guan-jin Wu1 ; Fu-ling Yan1 ; Erica Audrey Limbenga1 ; tresie05@yahoo.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ischemia ; Reperfusion ; Splenectomy ; TLR4 ; NF-κB ; Inflammation ; Neuroprotection
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：293
- 期：Complete
- 页码：105-113
- 全文大小：1378 K
文摘
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The spleen contributes to neurodegeneration after MCAO.
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Splenectomy following MCAO reduced infarct size in rats.
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Splenectomy following MCAO reduced the levels of TLR4 and NF-κB expression in the ischemic hemisphere.
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Splenectomy following MCAO reduced the cellular apoptosis in the ischemic hemisphere.
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We proposed that the spleen contributes to neurodegeneration after stroke by regulating the TLR4–NF-κB signaling pathway.