Suppression of macrophage-mediated phagocytosis of apoptotic cells by soluble β-glucan due to a failure of PKC-βII translocation
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- 作者：Suzuno Sekiguchi ; Yui Tomisawa ; Tomomi Ohki ; Kumiko Tsuboi ; Kisaburo Nagata ; Yoshiro Kobayashi ; yoshiro@biomol.sci.toho-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phagocytosis ; Apoptotic cells ; Macrophages ; β-Glucan ; PKC-βII ; Translocation
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：195-199
- 全文大小：518 K
文摘
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Phagocytosis of apoptotic cells was suppressed by soluble and particulate β-glucan.
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Phagocytosis of secondary necrotic cells was not suppressed by soluble β-glucan.
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Apoptotic cells induced PKC-βII translocation from the cytoplasm to membranes.
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PKC-βII translocation was inhibited by pretreatment with soluble β-glucan.