刊名:Journal of Pharmaceutical and Biomedical Analysis
出版年:2004
出版时间:April 16, 2004
年:2004
卷:35
期:2
页码:379-387
全文大小:417 K
文摘
The inclusion into the β-cyclodextrin is used to improve pharmacokinetic characteristics of hesperetin and naringenin. Solubility of hesperetin and naringenin with increasing concentrations of β-cyclodextrin grows as long as the temperature increased. Stability constants were determined by the solubility method by Higuchi and Connors at different temperatures, and the thermodynamic parameters were calculated for inclusion complex formation in aqueous solution. The solid complexes were obtained in a molar ratio of 1:1 and their dissolution behavior at different pH was examined.