Susceptibility of mantle cell lymphomas to reovirus oncolysis

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• 作者：Tommy Alain ; Huong Muzik ; Shannon Otsuka ; Salina Chan ; Tony Magliocco ; Roman Diaz ; Peter A. Forsyth ; Don Morris ; Gwyn Bebb
• 关键词：Reovirus ; Mantle cell lymphoma ; Ras activation ; Oncolysis ; SCID mice
• 刊名：Leukemia Research
• 出版年：2010
• 出版时间：January 2010
• 年：2010
• 卷：34
• 期：1
• 页码：100-108
• 全文大小：5417 K

文摘

Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro, we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras activation. In vivo, a single reovirus injection intra-tumorally resulted in complete regression of both the injected and the contra-lateral tumor in a subcutaneous bi-tumor model, in one out of three cell lines tested. Reovirus treatment of MCL seems feasible but will need to be guided by the presence of molecular determinants of reovirus susceptibility.