Modeling the layer V cortical pyramidal neurons showing theta-rhythmic firing in the presence of muscarine

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• 作者：Fukai ; Tomoki ; Kitano ; Katsunori ; Aoyagi ; Toshio ; Kang ; Youngnam
• 关键词：Theta oscillation ; Compartment neuron model ; Pyramidal neuron ; Muscarinic modulation
• 刊名：Neurocomputing
• 出版年：2002
• 出版时间：June, 2002
• 年：2002
• 卷：44-46
• 期：Complete
• 页码：103-108
• 全文大小：129 K

文摘

In this study, we model a type of layer V pyramidal neurons in the prefrontal cortex of rats. In the presence of muscarine, the pyramidal neurons exhibit a self-sustained rhythmic firing in the theta frequency range (4–7Hz) in response to a brief depolarizing step current. Since muscarine is known to activate the IP₃ receptors of the intracellular Ca²⁺ store, the sustained firing seems to occur due to the activation of a certain Ca²⁺-dependent current, presumably the Ca²⁺-activated nonselective cationic current, during the IP₃-induced Ca²⁺ release. Here we present a two-compartmental model neuron that shows the observed patterns of neuronal responses.