The effect of hepatocyte growth factor on secretory functions in human eosinophils
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- 作者：Yumiko Yamauchia ; Shigeharu Uekia ; ueki-shige@nifty.com" class="auth_mail" title="E-mail the corresponding author ; Yasunori Konnoa ; Wataru Itoa ; b ; Masahide Takedaa ; Yuka Nakamuraa ; Junko Nishikawaa ; Yuki Moritokia ; Ayumi Omokawaa ; Tomoo Sagaa ; Makoto Hirokawaa
- 关键词：BSA ; bovine serum albumin ; ETosis ; extracellular trap cell death ; FBS ; fetal bovine serum ; HGF ; hepatocyte growth factor ; TGF-β ; transforming growth factor-β ; VEGF ; vascular endothelial growth factor
- 刊名：Cytokine
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：45-50
- 全文大小：1140 K
文摘
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HGF significantly inhibited IL-5-induced secretion of TGF-β and VEGF from human eosinophils.
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HGF inhibited the secretory process mediated by piecemeal degranulation.
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In contrast, the inhibitory effect of HGF on ETosis-mediated cytolytic degranulation was limited.