Prognostic value of SUVmax measurements obtained by FDG-PET in patients with non-small cell lung cancer receiving chemotherapy
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- 作者：Yohei Imamura ; Koichi Azuma ; Seiji Kurata ; Satoshi Hattori ; Tetsuro Sasada ; Takashi Kinoshita ; Masaki Okamoto ; Tomotaka Kawayama ; Hayato Kaida ; Masatoshi Ishibashi ; Hisamichi Aizawa
- 关键词：NSCLC ; FDG-PET ; SUVmax ; PFS ; OS ; Chemotherapy
- 刊名：Lung Cancer
- 出版年：2011
- 出版时间：January 2011
- 年：2011
- 卷：71
- 期：1
- 页码：49-54
- 全文大小：291 K
文摘
[18F]Fluorodeoxyglucose (FDG) uptake has been shown to correlate well with tumor proliferation rates. In patients with non-small cell lung cancer (NSCLC) receiving chemotherapy, we analyzed the relationships between the maximum standardized uptake value (SUVmax) obtained by FDG positron emission tomography (FDG-PET) and other clinical factors, and examined whether or not SUVmax could predict progression-free survival (PFS) and/or overall survival (OS). This retrospective study involved 62 consecutive NSCLC patients (35 male and 27 female: median age, 65 years). All patients underwent FDG-PET examination before treatment. As the first-line treatment, the patients received chemotherapy with (n = 15) or without (n = 47) radiotherapy. Survival curves were obtained by the Kaplan–Meier method, and differences in survival between subgroups were analyzed by the log-rank test and the Cox proportional hazards model. Significant correlations were observed between SUVmax and gender (P = 0.006), histology (P < 0.001), smoking status (P = 0.049), stage (P = 0.015), and treatment modality (P = 0.008), but not other factors, including age (P = 0.402) and performance status (P = 0.421). The median SUVmax was 5.1 (25–75th percentile: 3.45–7.0) in patients with adenocarcinoma and 8.3 (25–75th percentile: 6.9–9.9) in those with other types of NSCLC. Adenocarcinomas showed significantly lower SUVmax than the other tumor types (P < 0.001). Cox analysis adjusting for possible confounding factors, including gender, smoking status, histology and stage, demonstrated that the hazard ratios increased as the SUVmax increased in terms of both PFS (P = 0.008) and OS (P = 0.045), indicating that SUVmax predicts outcome independently of other clinical factors, such as histology and stage. Our findings indicate that FDG-PET examination can provide information useful for prognostication in NSCLC.