Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities
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- 作者：Yutaka Aoyagi ; Yukio Hitotsuyanagi ; Tomoyo Hasuda ; Haruhiko Fukaya ; Koichi Takeya ; Ritsuo Aiyama ; Takeshi Matsuzaki and Shusuke Hashimoto
- 关键词：Triptolide analogues ; Semisynthesis ; Antitumor ; Structure– ; activity relationships ; C-ring
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2006
- 出版时间：1 April 2006
- 年：2006
- 卷：16
- 期：7
- 页码：1947-1949
- 全文大小：212 K
文摘
Several C-ring modified analogues of a potent antileukemic diterpene, triptolide (1), were synthesized and their structure–activity relationships were studied.