Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats

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• 作者：Burkhard ; Mary Jo ; Valenski ; Loretta ; Leavell ; Sarah ; Dean ; Gregg A. ; Tompkins ; Wayne A.F.
• 关键词：Venezuelan equine encephalitis (VEE) virus ; VEE-replicon particles ; Feline immunodeficiency virus (FIV)
• 刊名：Vaccine
• 出版年：2002
• 出版时间：December 13, 2002
• 年：2002
• 卷：21
• 期：3-4
• 页码：258-268
• 全文大小：244 K

文摘

Venezuelan equine encephalitis (VEE) virus-replicon particles (VRP) were used to generate feline immunodeficiency virus (FIV) Gag- and ENV-expressing vaccine vectors. Serum and mucosal FIV-specific antibody was detected in cats immunized subcutaneously, once monthly for 5 months, with FIV-expressing VRP. Expansion of the CD8+ l-selectin negative phenotype and transient CD8+ noncytolytic suppressor activity were seen in cats immunized with FIV-expressing or control VRP. Despite induction of FIV-specific immune responses and nonspecific suppressor responses, all cats became infected following vaginal challenge with high dose, pathogenic cell-associated FIV-NCSUb>1b> although relative early maintenance of CD4+ cells was seen in FIV-immunized cats.