- 作者：Colin Berry ; MBChB ; PhD? ; &dagger ; ; colin.berry@glasgow.ac.uk ; Marcel van 't Veer ; MSc ; PhD&Dagger ; ; Nils Witt ; MD ; PhD§ ; ; Petr Kala ; MD¡Î ; Otakar Bocek ; MD¡Î ; Stylianos A. Pyxaras ; MD¶ ; ; John D. McClure ; MSc ; PhD? ; William F. Fearon ; MD# ; Emanuele Barbato ; MD ; PhD¶ ; ; Pim A.L. Tonino ; MD ; PhD&Dagger ; ; Bernard De Bruyne ; MD ; PhD¶ ; ; Nico H.J. Pijls ; MD ; PhD&Dagger ; ; Keith G. Oldroyd ; MBChB ; MD&dagger ;
- 关键词：adenosine ; angina ; FFR ; hyperemia ; iFR
- 刊名：Journal of the American College of Cardiology
- 出版年：2013
- 出版时间：2 April, 2013
- 年：2013
- 卷：61
- 期：13
- 页码：1421-1427
- 全文大小：1689 K
lass=""h4"">Objectives
This study sought to compare fractional flow reserve (FFR) with the instantaneous wave-free ratio (iFR) in patients with coronary artery disease and also to determine whether the iFR is independent of hyperemia.lass=""h4"">Background
FFR is a validated index of coronary stenosis severity. FFR-guided percutaneous coronary intervention (PCI) improves clinical outcomes compared to angiographic guidance alone. iFR has been proposed as a new index of stenosis severity that can be measured without adenosine.
lass=""h4"">Methods
We conducted a prospective, multicenter, international study of 206 consecutive patients referred for PCI and a retrospective analysis of 500 archived pressure recordings. Aortic and distal coronary pressures were measured in duplicate in patients under resting conditions and during intravenous adenosine infusion at 140 ¦Ìg/kg/min.
lass=""h4"">Results
Compared to the FFR cut-off value of ¡Ü0.80, the diagnostic accuracy of the iFR value of ¡Ü0.80 was 60 % (95 % confidence interval [CI]: 53 % to 67 % ) for all vessels studied and 51 % (95 % CI: 43 % to 59 % ) for those patients with FFR in the range of 0.60 to 0.90. iFR was significantly influenced by the induction of hyperemia: mean ¡À SD iFR at rest was 0.82 ¡À 0.16 versus 0.64 ¡À 0.18 with hyperemia (p < 0.001). Receiver operating characteristics confirmed that the diagnostic accuracy of iFR was similar to resting Pd/Pa and trans-stenotic pressure gradient and significantly inferior to hyperemic iFR. Analysis of our retrospectively acquired dataset showed similar results.
lass=""h4"">Conclusions
iFR correlates weakly with FFR and is not independent of hyperemia. iFR cannot be recommended for clinical decision making in patients with coronary artery disease. (Comparison of Fractional Flow Reserve Versus Instant Wave-Free Ratio for Assessment of Coronary Artery Stenosis Severity in Routine Practice; )