GLI2 cell-specific activity is controlled at the level of transcription and RNA processing: Consequences to cancer metastasis
详细信息 查看全文
- 作者：Helle Sadama ; b ; 1 ; Urmas Liivasa ; 1 ; Anna Kazantsevaa ; b ; Priit Pruunsildb ; Jekaterina Kazantsevaa ; Tõ ; nis Timmuskb ; Toomas Neumana ; Kaia Palma ; b ; kaia@protobios.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：GLI2 ; Alternative splicing ; RNA processing ; Cancer ; Invasion
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1862
- 期：1
- 页码：46-55
- 全文大小：1498 K
文摘
- •
RNA processing is the key process determining tissue-specific activity of GLI2.
- •
Usage of alternative transcription initiation/termination sites generates N- and C-terminally truncated GLI2.
- •
High expression of N- and C-terminally truncated GLI2 is coupled to melanoma invasion.
- •
RNA processing of GLI2 is TGFbeta-dependent in melanoma