Blocking of TRPV-1 in the parodontium relieves orthodontic pain by inhibiting the expression of TRPV-1 in the trigeminal ganglion during experimental tooth movement in rats
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- 作者：Yunan Gaoa ; b ; Yingfei Liub ; Kun Zhub ; Zhichao Zhangb ; Hu Qiaoa ; Zhen Lua ; Tianyu Zhonga ; b ; Yong Liub ; liuy5599@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hong Zhoua ; zhouhong@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：TRPV1 ; transient receptor potential vanilloid type 1 ; TG ; trigeminal ganglion ; TRP ; transient receptor potential ; PFA ; paraformaldehyde ; qRT-PCR ; quantitative realtime PCR ; DMSO ; dimethylsulfoxide ; GCF ; gingival crevicular fluid ; IL-1β ; interleukin-1β
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：628
- 期：Complete
- 页码：67-72
- 全文大小：1610 K
文摘
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Experimental tooth movement increases the expression of TRPV1 in the parodontium.
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TRPV1 activation in the parodontium increases the expression of TRPV1 in the trigeminal ganglion.
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TRPV1 blockade in the parodontium decreases orthodontic pain by reducing the expression of TRPV1 in the trigeminal ganglion.