Age-related disorders of sleep and motor control in the rat models of functionally distinct cholinergic neuropathology
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- 作者：Jelena Cirica ; Katarina Lazica ; Jelena Petrovica ; Aleksandar Kalauzib ; Jasna Saponjica ; jasnasap@ibiss.bg.ac.rs" class="auth_mail" title="E-mail the corresponding author ; jasnasaponjic@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aging ; Sleep ; Cortical drive ; The pedunculopontine tegmental nucleus ; The nucleus basalis ; Cholinergic neuronal loss
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：273-286
- 全文大小：6115 K
文摘
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We studied the aging impact in the rat models of distinct cholinergic neuropathology.
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We demonstrated age-related and topographically specific EEGs and cortical drives.
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Attenuated REM delta amplitude was the hallmark of aging onset in the NB lesion.
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Augmented REM sigma amplitude was the hallmark of aging in the PPT lesion.
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Disorders of REM sleep and cortical drives are the hallmarks of pathological aging onset.