Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor
文摘
A new class of dual topo inhibitors, 2,4-substituted diphenyl benzofuro[3,2-b]pyridines were prepared. Observed positive correlation with dual topo inhibition and antiproliferative activity. Benzofuran moiety and phenol on 4-position of central pyridine is crucial for both activity. Compound 14 acts as a non-intercalative catalytic dual topo I and II inhibitor.