Therapeutic implication of mTORC2 in oral squamous cell carcinoma

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• 作者：Tomofumi Naruse^a ; ^{naruse12@nagasaki-u.ac.jp} ; Souichi Yanamoto^a ; Kohei Okuyama^a ; Kentaro Yamashita^a ; Keisuke Omori^a ; Yuji Nakao^b ; Shin-ichi Yamada^b ; Masahiro Umeda^a
• 关键词：mTORC2 ; Rictor ; SGK1 ; Torin-1 ; Cetuximab
• 刊名：Oral Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：65
• 期：Complete
• 页码：23-32
• 全文大小：3361 K
• 卷排序：65

文摘

mTORC2 axis expression is associated with cancer progression. Torin-1 inhibits proliferation of oral squamous cell carcinoma cells. Combined Torin-1 and cetuximab treatment may have additional therapeutic benefit.