Randomized, double-blind, placebo-controlled, parallel-group trial.
Women's health clinical research unit at a university hospital.
Two-hundred healthy, naturally postmenopausal women aged 50–65 years.
Randomization to 4 weeks' treatment with testosterone (testosterone undecanoate, 40 mg/day), estrogen (oral E<sub>2sub> 2 mg/day) or placebo.
Comparisons in verbal fluency, verbal memory, and spatial ability between the three treatment groups.
We found no significant effects of testosterone or estrogen on verbal fluency, verbal memory, or spatial ability.
Our results give no support for short-term testosterone or estrogen treatment having any substantial effect on verbal fluency, verbal memory, or spatial ability in healthy postmenopausal women.