Hemodynamic characteristics of midazolam, propofol, and dexmedetomidine in healthy volunteers

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• 作者：Michael A. Fr&#xf6 ; lich MD ; MS<sup>asup><sup> ; sup><sup>froelich@uab.edu"" rel=""nofollowsup> ; Associate Professor ; Alireza Arabshahi<sup>bsup> ; Research Associate ; Charles Katholi PhD<sup>csup> ; Professor Emeritus ; Jeevan Prasain PhD<sup>bsup> ; Assistant Professor ; Stephen Barnes PhD<sup>bsup> ; Professor of Pharmacology ; Toxicology
• 关键词：Dexmedetomidine ; Hemodynamics ; Midazolam ; Propofol ; Sedation ; intravenous
• 刊名：Journal of Clinical Anesthesia
• 出版年：2011
• 出版时间：May 2011
• 年：2011
• 卷：23
• 期：3
• 页码：218-223
• 全文大小：471 K

文摘

ss=""h4"">Study Objective

To study the effect of intravenous (IV) sedation on blood pressure (BP), heart rate (HR), and respiratory rates (RR) to determine if IV sedatives differ with respect to their effect on BP, HR, and RR.

ss=""h4"">Design

Prospective, randomized, single-blinded, placebo-controlled study.

ss=""h4"">Setting

Monitored patient care room at a clinical research center.

ss=""h4"">Subjects

60 healthy ASA physical status 1 volunteers.

ss=""h4"">Interventions

Subjects were randomized to receive, in increasing doses, one of three IV sedatives: propofol, midazolam, or dexmedetomidine; or saline control.

ss=""h4"">Measurements

Blood pressure (systolic, diastolic), HR, and RR were recorded.

ss=""h4"">Main Results

A significant dose-dependent BP reduction occurred with dexmedetomidine and, to a lesser degree, with propofol; and there was good agreement of predicted versus measured drug concentrations for all sedatives. Blood pressure and HR of participants who received midazolam did not change.

ss=""h4"">Conclusions

When administered in sedative doses, dexmedetomidine and, to a lesser extent, midazolam, reduces BP in a dose-dependent fashion. Dexmedetomidine also reduces HR. Midazolam does not affect BP or HR.