Green tea polyphenol epigallocatechin-3-gallate inhibits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90
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- 作者：Sakata ; Ryuichiro ; Ueno ; Takato ; Nakamura ; Toru ; Sakamoto ; Masaharu ; Torimura ; Takuji ; Sata ; Michio
- 关键词：Liver fibrosis ; Cell signal transduction ; Liver cirrhosis ; DMEM ; Dulbecco's modified essential medium ; BrdU ; bromodeoxy-uridine ; ECM ; extracellular matrix ; EGCG ; epigallocatechin-3-gallate ; FBS ; fetal bovine serum ; HSC ; hepatic stellate cells ; PDGF ; plate
- 刊名：Journal of Hepatology
- 出版年：2004
- 出版时间：January, 2004
- 年：2004
- 卷：40
- 期：1
- 页码：52-59
- 全文大小：295 K
文摘
Background/Aims: Green-tea polyphenols are known to have anti-fibrotic properties of the skin and the artery. The proliferation of hepatic stellate cells (HSC) is closely related to the progression of liver fibrosis in chronic liver diseases. We investigated the inhibitory effect of epigallocatechin-3-gallate (EGCG), the major potential inhibitory component of green-tea polyphenols, on the proliferation of HSC. The aim of this study was to clarify the molecular mechanisms of EGCG inhibition of HSC proliferation.