Laminin deposition to type IV collagen enhances haptotaxis, chemokinesis, and adhesion of hepatoma cells through β1-integrins
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- 作者：Torimura ; Takuji ; Ueno ; Takato ; Kin ; Motoaki ; Harada ; Riko ; Nakamura ; Toru ; Sakamoto ; Masaharu ; et. al.
- 关键词：Hepatoma ; Cell motility ; Adhesion ; β ; 1-integrins ; Laminin ; Type IV collagen ; Metastasis ; Invasion ; Basement membrane
- 刊名：Journal of Hepatology
- 出版年：2001
- 出版时间：August, 2001
- 年：2001
- 卷：35
- 期：2
- 页码：245-253
- 全文大小：984 K
文摘
Background/Aims: In hepatocellular carcinoma, laminin deposition to type IV collagen along the sinusoids is observed with the development of arterial network, coinciding with intrahepatic metastasis. We investigated the influence of laminin deposition to type IV collagen on hepatoma cell adhesion, motility and secretion of matrix metalloproteinases (MMPs), which are indispensable behaviors for tumor metastasis.