- 作者：Ethel Codner ; Francisca C. Eyzaguirre ; Germá ; n Iñ ; iguez ; Patricia Ló ; pez ; Francisco Pé ; rez-Bravo ; Isabel M. Torrealba ; Fern ; o Cassorla ; Chilean Group for the Study of Ovarian Function in Type 1 Diabetes
- 关键词：Adolescence ; fertility ; menarche ; ovarian function ; ovulation ; pregnancy ; puberty ; type 1 diabetes mellitus
- 刊名：Fertility and Sterility
- 出版年：2011
- 出版时间：January 2011
- 年：2011
- 卷：95
- 期：1
- 页码：197-202.e1
- 全文大小：178 K
Objective
To study ovulation in adolescents with type 1 diabetes (T1D) and the effect of hemoglobin A1c (HbA1c) levels on their ovulatory function.Design
Prospective investigation.
Setting
Academic research institute.
Patient(s)
Adolescents with T1D (n = 31) and healthy girls (n = 52).
Intervention(s)
Ovulation assessed through the measurement of salivary progesterone (days 13, 18, 23, and 28 of each cycle).
Main Outcome Measure(s)
Proportion of ovulatory cycles.
Result(s)
A total of 168 and 281 menstrual cycles were studied in the T1D and control girls, respectively. Metabolic control was defined as optimal if HbA1c was <7.5 % . The proportion of ovulatory cycles was similar in the TID and control groups (34.5 % and 36.3 % , respectively). Regression analyses showed that the presence of T1D did not have a statistically significant effect on the ovulatory rate. However, more ovulatory cycles were observed in girls with T1D who had optimal metabolic control compared with those who had insufficient control (51.3 % vs. 29.4 % ).
Conclusion(s)
In adolescent girls, T1D did not affect the rate of ovulation. A higher ovulatory rate was observed in those with optimal control compared with those with insufficient metabolic control, but a substantial proportion of ovulatory cycles were still observed in patients with higher HbA1c levels.