- 作者：Vicen? Torrente-Segarra ; Maria P. Lisbona ; Delf¨ª Rot¨¦s-Sala ; Juan Mu?oz-Ortego ; Isabel Padr¨®-Blanch ; Joan Maym¨®-Guarch ; Josep M. Manresa Dom¨ªnguez ; Jordi Carbonell-Abell¨®
- 关键词：Systemic lupus erythematosus ; Hand ; Joint ; Ultrasound ; Quality of life ; Disability
- 刊名：Joint Bone Spine
- 出版年：2013
- 出版时间：July, 2013
- 年：2013
- 卷：80
- 期：4
- 页码：402-406
- 全文大小：544 K
Objective
Systemic lupus erythematosus (SLE) is an autoimmune disease which may has joint impairment. Often, SLE patients complain of hand and wrist arthralgia (HA). Usually, these patients do not show any swelling in the physical exam. Our aim was to demonstrate Power Doppler Ultrasound (PDUS) abnormalities in SLE patients with HA.Methods
We recruited 58 consecutive SLE patients and divided them into two groups: case group (n = 28) were patients with HA, and control group (n = 30) were patients without HA. We also collected socio-demographic and disease activity data, biological markers and SLEDAI index. We evaluated disability and quality of life by mHAQ and SF-12, respectively. We performed a bilateral hand and wrist PDUS on all patients. PDUS findings were based in OMERACT-7 group criteria.
Results
We found PDUS abnormalities in most of SLE patients who suffered HA, when compared to SLE controls (P < 0.001). The main findings in Case Group were: tenosynovitis (39.2 % ), synovial effusion or hypertrophy (25 % ) and active synovitis (14.2 % ). SLEDAI score and dsDNA antibodies were related to the presence of PDUS abnormalities (P < 0.05 and P < 0.001, respectively). We also found worse physical SF-12 (P < 0.05) and mHAQ (NS) scores in case group.
Conclusions
SLE patients who present HA have more PDUS abnormalities. These findings are associated with a higher SLEDAI score and dsDNA antibodies. This articular affection may contribute to a worsened functional ability and a lower quality of life. PDUS seems to be a reliable tool in the assessment of SLE patients with HA.