Effects of a higher dose of near-infrared light on clinical signs and neuroprotection in a monkey model of Parkinson's disease
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- 作者：Cé ; cile Moroa ; cecile.moro@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Nabil El Massrib ; nabil.elmassri@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Fannie Darlota ; fannie.darlot@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Napoleon Torresa ; napoleon.torres@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Claude Chabrola ; cl.chabrol@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Diane Agaya ; diane.agay@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Vincent Auboirouxa ; vincent.auboiroux@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Daniel M. Johnstonec ; daniel.johnstone@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Jonathan Stonec ; jonathan.stone@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; John Mitrofanisb ; john.mitrofanis@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Alim-Louis Benabida ; alimlouis@sfr.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tyrosine hydroxylase ; Substantia nigra ; MPTP ; Macaque monkeys ; Behaviour ; 670 ; nm
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PA
- 页码：19-26
- 全文大小：2093 K
文摘
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Near infrared light delivered intracranially at high dose is not toxic to brain.
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Compared to lower NIr doses, higher doses are less beneficial after MPTP insult.
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Clinical impairment after MPTP insult not improved greatly with higher NIr dose.
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Neuroprotection after MPTP insult not substantial after higher NIr dose.