Label free bio image sensor for real time monitoring of potassium ion released from hippocampal slices
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- 作者：Akiteru Konoa ; kono-a@int.ee.tut.ac.jp" class="auth_mailAuthor Vitae ; Takashi Sakuraib ; cAuthor Vitae ; Toshiaki Hattoria ; cAuthor Vitae ; Koichi Okumuraa ; cAuthor Vitae ; Makoto Ishidaa ; bAuthor Vitae ; Kazuaki Sawadaa ; b ; cAuthor Vitae
- 关键词：CMOS biosensor ; Potassium ion image sensor ; PVC membrane ; Label free detection ; Hippocampus
- 刊名：Sensors and Actuators B: Chemical
- 出版年：1 October 2014
- 年：2014
- 卷：201
- 期：Complete
- 页码：439-443
- 全文大小：1421 K
文摘
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K+ image sensor was developed using a PVC membrane coated on a 128 × 128 pixels CCD pH image sensor.
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The sensitivity was 50 mV/decade for a K+ concentration of 10−3 to 10−1 M.
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Glutamate-induced changes in the K+ were recorded in the hippocampal slices.
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The imaging of K+ release from hippocampal neurons was demonstrated without labeling.