Relationship between signal intensity on hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging and prognosis of borderline lesions of hepatocellular carcinoma

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• 作者：Satoshi Kobayashi ; Osamu Matsui ; Toshifumi Gabata ; Wataru Koda ; Tetsuya Minami ; Yasuji Ryu ; Kazuto Kozaka ; Azusa Kitao
• 关键词：Gd-EOB-DTPA ; MRI ; Hepatocellular carcinoma ; Borderline lesions
• 刊名：European Journal of Radiology
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：81
• 期：11
• 页码：3002-3009
• 全文大小：1374 K

文摘

Purpose

To elucidate the incidence of signal intensity patterns of borderline lesions of hepatocellular carcinoma (HCC) on hepatobiliary phase Gd-EOB-DTPA (EOB) enhanced MRI and clarify the natural histories of these lesions.

Materials and methods

Total 99 borderline lesions of HCC were identified by angiography-assisted CT. The signal intensity of borderline lesions on hepatobiliary phase of EOB-enhanced MRI was analyzed. Progress rate from borderline lesions to hypervascular HCC was calculated with the Kaplan-Meier method among each signal intensity groups of nodules.

Results

On hepatobiliary phase of EOB-enhanced MRI, 41.4 % of the borderline lesions showed hypo-, 42.4 % showed iso-, and 16.2 % showed hyperintense, compared to background liver. Overall progress rates from borderline lesions to HCC were 10 % in 1-year, 14 % in 2-year and 20 % in 3-year follow-up period. Progress rates to HCC in hypointense borderline lesions were 17 % in 1-year, 28 % in 2-year and 41 % in 3-year follow-up period, and in isointense borderline lesions were 7 % in 1-year, 7 % in 2-year and 7 % in 3-year follow-up period. No hyperintense borderline lesions progressed to HCC in follow-up period.

Conclusion

Although borderline lesions of HCC may show hypo-, iso- and hyperintensity on hepatobiliary phase of EOB-enhanced MRI, hypointense borderline lesions are high risk to progress HCC.