Dietary unripe apple polyphenol inhibits the development of food allergies in murine models

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• 作者：Hiroshi Akiyama ; Yuji Sato ; Takahiro Watanabe ; Megumi H. Nagaoka ; Yasuo Yoshioka ; Toshihiko Shoji ; Tomomasa Kanda ; Kiyoshi Yamada ; Mamoru Totsuka ; Reiko Teshima et al.
• 关键词：Apple condensed tannin ; IgE ; Food allergy ; Oral sensitization ; Intestinal intraepithelial lymphocytes ; TCRγ ; δ ; -T cell
• 刊名：FEBS Letters
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：579
• 期：20
• 页码：4485-4491
• 全文大小：237 K

文摘

The incidence of type I allergic disorders has been increasing worldwide, particularly, the hypersensitivity to food. We first showed that apple condensed tannin (ACT) intake would inhibit the development of the oral sensitization and that the inhibition could correlate with the rise in the population of TCRγδ-T cells in the intestinal intraepithelial lymphocytes (IEL) using W/W^V mice and B10A mice which were ovalbumin (OVA)-orally sensitized. Serum OVA-specific immunoglobulin E and immunoglobulin G1 titers in the OVA-orally sensitized W/W^V and B10A mice ad libitium fed ACT were extremely inhibited compared to those of the control. The ACT intakes of OVA-sensitized W/W^V and B10A mice inhibited the immediate reduction of the body temperature or the rise in serum histamine induced by active systemic anaphylaxis. The proportions of the TCRγδ-T cells in the IEL of the OVA-orally sensitized W/W^V and B10A mice ad libitium fed ACT were significantly greater than that in the controls. Furthermore, ACT feeding by itself could induce the rise in the percentage of the TCRγδ-T cells among the IEL of the W/W^V and B10A mice. This suggests that the ACT intake may prevent the development of food allergies and this effect could be correlated with the rise in the percentage of TCRγδ-T cells among the IEL.