Digital Assessment of Endothelial Function and Ischemic Heart Disease in Women

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• 作者：Yasushi Matsuzawa ; Seigo Sugiyama ; Koichi Sugamura ; Toshimitsu Nozaki ; Keisuke Ohba ; Masaaki Konishi ; Junichi Matsubara ; Hitoshi Sumida ; Koichi Kaikita ; Sunao Kojima ; Yasuhiro Nagayoshi ; Megumi Yamamu
• 关键词：myocardial ischemia ; endothelium ; women
• 刊名：Journal of the American College of Cardiology
• 出版年：2010
• 出版时间：20 April 2010
• 年：2010
• 卷：55
• 期：16
• 页码：1688-1696
• 全文大小：1209 K

文摘

Objectives

We investigated the utility of digital reactive hyperemia peripheral arterial tonometry (RH-PAT) in predicting ischemic heart disease (IHD), including obstructive coronary artery disease (CAD) and nonobstructive coronary artery disease (NOCAD), in women.

Background

IHD is the leading cause of mortality, and its pathogenesis is diverse in women. Fingertip RH-PAT is a new device that provides noninvasive, automatic, and quantitative evaluation of endothelial dysfunction.

Methods

RH-PAT was measured using Endo-PAT2000 (Itamar Medical, Caesarea, Israel) before cardiac catheterization in 140 stable women scheduled for hospitalization to examine chest pain. NOCAD was diagnosed by angiography with measurement of coronary blood flow and cardiac lactate production during intracoronary acetylcholine provocation test and cardiac scintigraphy with stress tests.

Results

Sixty-eight women (49 % ) had obstructive CAD and 42 women (30 % ) had NOCAD. RH-PAT indexes were significantly attenuated in both obstructive CAD and NOCAD as compared with non-IHD (n = 30) (obstructive CAD: median 1.57, interquartile range [IQR] 1.42 to 1.76; NOCAD: median 1.58, IQR 1.41 to 1.78; non-IHD: median 2.15, IQR 1.85 to 2.48, p < 0.001). By multivariate logistic regression analysis, only RH-PAT index was significantly associated with IHD, including obstructive CAD and NOCAD (odds ratio 0.51; 95 % confidence interval: 0.38 to 0.68; p < 0.001). In receiver-operating characteristic analysis, RH-PAT index was a significant predictor of IHD (area under the curve 0.86; p < 0.001). Furthermore, only RH-PAT was useful for the prediction of NOCAD after excluding obstructive CAD (area under the curve 0.85; p < 0.001; RH-PAT index of <1.82 had 81 % sensitivity and 80 % specificity).

Conclusions

RH-PAT indexes were significantly attenuated in women with IHD. Digital RH-PAT can predict patients with IHD, especially NOCAD before angiography. RH-PAT is potentially useful for identifying high-risk women for IHD. (Endothelial Dysfunction and Coronary Artery Spasm; NCT00619294)