Serum TGF-beta1 level increases during early postmenopause and declines in old age.
Serum TGF-beta1 level was significantly related to level of bone turnover markers.
Serum sclerostin level was positively correlated with BMD and negatively with serum PTH.
Serum sclerostin level was positively associated with age in premenopausal women.
Sclerostin production is inhibited by TGF-beta1 during early postmenopause.