Circulating TGF-β1 levels are negatively correlated with sclerostin levels in early postmenopausal women
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- 作者：Qun Chenga ; b ; quncheng_2014@163.com" class="auth_mail" title="E-mail the corresponding author ; Wenjing Tanga ; b ; Tzong-Jen Sheuc ; Yanping Dua ; b ; Jiemin Ganb ; d ; Huilin Lia ; b ; Wei Honga ; b ; Xiaoying Zhua ; b ; Sihong Xuea ; b ; Xuemei Zhanga ; b
- 关键词：TGF-β1 ; transforming growth factor β 1 ; SOST ; sclerostin ; L1-4 ; BMD of lumbar spine 1&ndash ; 4 ; FN ; BMD of femur neck ; Total hip ; BMD of total hip ; P1NP ; N-terminal propeptide of type I collagen ; PTH ; parathyroid hormone ; VitD ; serum 25(OH)D ; CTX ; cross-linked C-telopeptide of type I collagen ; BGP ; osteocalcin ; ALP ; alkaline phosphatase ; FSH ; follicle stimulating hormone ; E2 ; estradiol ; Cr ; creatinine
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：455
- 期：Complete
- 页码：87-92
- 全文大小：414 K
文摘
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Serum TGF-beta1 level increases during early postmenopause and declines in old age.
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Serum TGF-beta1 level was significantly related to level of bone turnover markers.
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Serum sclerostin level was positively correlated with BMD and negatively with serum PTH.
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Serum sclerostin level was positively associated with age in premenopausal women.
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Sclerostin production is inhibited by TGF-beta1 during early postmenopause.