• 作者：Jintanat Ananworanich^a ; ^b ; ^c ; ^{jananworanich@hivresearch.org" class="auth_mail" title="E-mail the corresponding author} ; Nicolas Chomont^d ; ^e ; ¹ ; Leigh Ann Eller^a ; ^b ; Eugene Kroon^c ; ^f ; Sodsai Tovanabutra^a ; ^b ; Meera Bose^a ; ^b ; Martin Nau^a ; ^b ; James L.K. Fletcher^c ; Somporn Tipsuk^c ; Claire Vandergeeten^e ; ¹ ; Robert J. O'Connell^d ; Suteeraporn Pinyakorn^a ; ^b ; Nelson Michael^a ; Nittaya Phanuphak^c ; Merlin L. Robb^a ; ^b ; on behalf of the RV217 ; RV254/SEARCH010 study groups
• 关键词：Acute HIV infection ; Art ; HIV DNA ; Reservoir ; Persistence
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：11
• 期：Complete
• 页码：68-72
• 全文大小：395 K

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The HIV DNA set-point is established early in acute HIV infection.

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Over three years without antiretroviral therapy, persons with acute HIV infection have total HIV DNA in peripheral blood mononuclear cells that is 300-fold and integrated HIV DNA that is 100-fold higher than those on treatment.

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Early antiretroviral therapy provides an opportunity to markedly reduce proviral HIV DNA burden,

HIV is difficult to cure because it infects long-lived cells in the body, also called “reservoirs”. Having a small HIV reservoir size may benefit health. We show that HIV DNA in peripheral blood cells, a marker of the HIV reservoir size, establishes a set-point level during the first 6 weeks of infection and changes little over time without HIV medications. However, if HIV medications are started early, the reservoir size declines rapidly, and is 300-fold lower than that seen in untreated persons. Currently the most effective way to significantly lower the HIV reservoir size is with very early treatment.