Novel application of statistical methods for analysis of multiple toxicants identifies DDT as a risk factor for early child behavioral problems
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- 作者：Joan Fornsa ; Siddhartha Mandala ; Nina Iszatta ; Anuschka Polderb ; Cathrine Thomsenc ; Jan Ludvig Lyched ; Hein Stigume ; Roel Vermeulenf ; Merete Eggesbø ; a ; Merete.eggesbo@fhi.no" class="auth_mail" title="E-mail the corresponding author
- 关键词：POPs ; persistent organic pollutants ; PCBs ; polychlorinated biphenyls ; p ; p&prime ; -DDT ; 1 ; 1 ; 1-trichloro-2 ; 2-bis (4chlorophenyl) ethane ; p ; p&prime ; DDE ; 1 ; 1-dichloro-2 ; 2-bis (p-chlorophenyl) ethylene ; HCB ; Hexachlorobenzene ; ß ; -HCH ; ß ; -hexachlorocyclohexane ; PBDEs ; polybrominateddiphenyl et ; PCA ; principal component analysis ; ENET ; elastic net ; BMA ; Bayesian model averaging ; HUMIS ; Norwegian Human Milk Study ; NIPH ; Norwegian Institute of Public Health ; GC&ndash ; MS ; liquid-liquid extraction
- 刊名：Environmental Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：91-100
- 全文大小：795 K
文摘
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We investigated 24 POPs measured in breast milk and early behavioral problems.
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Principal component analysis, elastic net and Bayesian model averaging identified influential toxicants.
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All three methods found p,p′-DDT associated with behavioral problems at 12 months.
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The p,p′-DDT-behavioral problem association was stronger in lower educated mothers' children.