Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity

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• 作者：Qiaosha Zhu^a ; ¹ ; Yang Qian^b ; ¹ ; Ying Yang^a ; Weifeng Wu^a ; Jingli Xie^a ; ^c ; ^{jlxie@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Dongzhi Wei^a ; ^c
• 关键词：carbonyl iron powder ; iron deficiency anemia ; iron supplements ; subchronic toxicity
• 刊名：Journal of Food and Drug Analysis
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：24
• 期：4
• 页码：746-753
• 全文大小：1528 K

文摘

Carbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentration of erythrocytes of IDA rats to the normal level after 8 days. The no observed adverse effect level of CIP in rats was considered to be > 200 mg/kg. The hematological and serum biochemical parameters of the rats did not differ significantly between the control and treated groups. There were no morphological changes observed in the organs including liver, kidneys, spleen, testes, stomach and intestine. Therefore, CIP might be a safe iron supplement.