Evolution of cytokine profile during the treatment of cerebral toxoplasmosis in HIV-infected patients
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- 作者：Cristina da Silva Meiraa ; Vera Lucia Pereira-Chioccolaa ; pchioccola@gmail.com" class="auth_mail" title="E-mail the corresponding author ; José ; Ernesto Vidalb ; Gabriela Motoiea ; Thaí ; s Alves da Costa-Silvaa ; Ricardo Gavaa ; Toxoplasma Group1 Toxoplasma Group
- 关键词：Toxoplasma gondii ; Cerebral toxoplasmosis ; Toxoplasmosis ; Central nervous system ; Cytokines ; Immune system ; Acquired immunodeficiency syndrome
- 刊名：Journal of Immunological Methods
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：426
- 期：Complete
- 页码：14-18
- 全文大小：537 K
文摘
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Cytokines were evaluated in cerebral toxoplasmosis/HIV infected patients in treatment.
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IFN-γ, TNF-α and IL-10 levels were determined in PBMC samples of patients.
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They had low IFN-γ with discrete increase during treatment.
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They had high TNF-α in the beginning; and decrease during treatment.
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Evolution of the infection was correlated to IFN-γ restoration and inflammation decrease.