Expression of syndecan-1 is common in human lung cancers independent of expression of epidermal growth factor receptor

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• 作者：Toyoshima ; Eri ; Ohsaki ; Yoshinobu ; Nishigaki ; Yutaka ; Fujimoto ; Yoshinori ; Kohgo ; Yutaka ; Kikuchi ; Kenjiro
• 关键词：Lung cancer ; Heparan sulfate proteoglycan ; Syndecan-1 ; Epidermal growth factor receptor ; Transforming growth factor-β
• 刊名：Lung Cancer
• 出版年：2001
• 出版时间：March, 2001
• 年：2001
• 卷：31
• 期：2-3
• 页码：193-202
• 全文大小：375 K

文摘

In order to determine syndecan-1 expression in lung cancer, we examined 115 lung cancer specimens and 17 lung cancer cell lines. Syndecan-1 was immunohistochemically stained with a polyclonal antibody in 115 paraffin-embedded specimens; 84 cases out of 97 non-small cell lung cancer (NSCLC) and eight cases out of 18 small cell lung cancer (SCLC) were positively stained. Simultaneously, epidermal growth-factor receptor (EGFR) was stained; 47 cases out of 97 NSCLC and one case of 18 SCLC were positively stained. No significant correlation was shown between EGFR and syndecan-1 expression (P