Up-regulation of GTPBP4 in colorectal carcinoma is responsible for tumor metastasis
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- 作者：Haitao Yua ; Sufeng Jinb ; Na Zhangc ; Qi Xud ; xuq_2015@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：GTPBP4 ; CRC ; Metastasis ; Actin cytoskeleton ; RhoA activity
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：4 November 2016
- 年：2016
- 卷：480
- 期：1
- 页码：48-54
- 全文大小：1369 K
文摘
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Up-regulation of GTPBP4 is detected in CRC metastatic tissues and closely correlated with tumor metastasis.
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Increase of GTPBP4 is closely associated with poor prognosis.
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GTPBP4 promotes cell motility and tumor metastasis in CRC cells.
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GTPBP4 induces filamentous actin rearrangement specifically by repressing the activity of RhoA.
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GTPBP4 may be a novel therapeutic target for CRC patients with metastasis.