Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood
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- 作者：R. Hiroia ; b ; rhiroi@asu.edu" class="auth_mail" title="E-mail the corresponding author ; D.L. Carbonea ; david.carbone@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author ; D.G. Zuloagaa ; &Dagger ; ; dzuloaga@albany.edu" class="auth_mail" title="E-mail the corresponding author ; H.A. Bimonte-Nelsonb ; bimonte.nelson@asu.edu" class="auth_mail" title="E-mail the corresponding author ; R.J. Handaa ; &dagger ; ; bhanda@colostate.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; serotonin ; cDRN ; caudal dorsal raphe nucleus ; DEX ; dexamethasone ; DRN ; dorsal raphe nucleus ; FST ; forced swim test ; GC ; glucocorticoids ; GD ; gestational day ; LDT ; light-dark transition box ; OFT ; open field test ; P or PND ; postnatal day ; qRT-PCR ; quantitative reverse-transcriptase polymerase chain reaction ; rDRN ; rostral dorsal raphe nucleus ; TpH2 ; tryptophan hydroxylase-2
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：320
- 期：Complete
- 页码：43-56
- 全文大小：798 K
文摘
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Prenatal dexamethasone increased anxiety- and despair- like behaviors in females.
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Prenatal dexamethasone increased TpH2 mRNA in female caudal DRN at P7.
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Prenatal dexamethasone decreased TpH2 mRNA in female caudal DRN in adulthood.
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Stress-challenged females with prenatal dexamethasone had lower TpH2 in rostral DRN.
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All prenatal dexamethasone effects were found selectively in females but not males.