Dose-dependent inhibition of uterine contractility by nitric oxide: A potential mechanism underlying persistent breeding-induced endometritis in the mare

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• 作者：Firdous A. Khan^a ; ^{firdous@uoguelph.ca} ; Tracey S. Chenier^a ; Coral L. Murrant^b ; Robert A. Foster^c ; Joanne Hewson^d ; Elizabeth L. Scholtz^a
• 关键词：Equine ; Nitric oxide ; Uterine contractility ; Breeding-induced endometritis
• 刊名：Theriogenology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：59-64
• 全文大小：492 K
• 卷排序：90

文摘

Treatment with SNAP, a nitric oxide donor, caused a dose-dependent inhibition of spontaneous uterine contractility. The effect of SNAP treatment on uterine contractility was not influenced by age or weight of the mare. The effect was also not influenced by stage of estrous cycle, uterine histology grade, or uterine muscle layer. Stage of estrous cycle, uterine histology grade, and age had significant main effects on spontaneous uterine contractility. This study indicates that nitric oxide causes a dose-dependent inhibition of spontaneous uterine contractility in the mare.