Dual-modality NIRF-MRI cubosomes and hexosomes: High throughput formulation and in vivo biodistribution

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• 作者：Nhiem Tran^a ; ^b ; ^c ; ¹ ; ^{nhiem.tran@rmit.edu.au} ; Nicole Bye^d ; ¹ ; ² ; Bradford A. Moffat^d ; David K. Wright^d ; ^e ; Andrew Cuddihy^f ; Tracey M. Hinton^g ; Adrian M. Hawley^b ; Nicholas P. Reynolds^a ; ^h ; Lynne J. Waddington^a ; Xavier Mulet^a ; Ann M. Turnley^d ; M. Cristina Morganti-Kossmannⁱ ; ^j ; Benjamin W. Muir^a ; ^{ben.muir@csiro.au}
• 关键词：Lipid ; Nanoparticles ; Cubosome ; Hexosome ; Multifunctional ; Imaging ; MRI ; Biodistribution
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：584-593
• 全文大小：2544 K
• 卷排序：71

文摘

Dual modality NIRF-MR imaging self-assembled lipid nanoparticles were formulated. The nanoparticles showed cubic and hexagonal internal nanostructures. Biodistribution experiments revealed accumulation of both cubosomes and hexosomes in spleen and liver of mice. Pre-clinical MRI displayed enhanced contrast in spleen and liver of mice that received either cubosomes or hexosomes.