An ounce of prevention: A pre-randomization protocol to improve retention in substance use disorder clinical trials
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Missing data are a problem for valid inference in all areas of research.

Substance use disorder researchers routinely report over 20% missing data points.

Before randomization, a thorough real-world discussion of all potential retention threats may improve attendance/adherence.

Adherence and complete data points were each over 90% following implementation of a pre-randomization retention protocol.

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