TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE−/− mice
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- 作者：Siva Sankara Vara Prasad Sakamuria ; 3 ; 4 ; Yusuke Higashia ; 2 ; 4 ; Sergiy Sukhanova ; 2 ; 4 ; Jalahalli M. Siddeshaa ; 1 ; Patrice Delafontainea ; 2 ; Ulrich Siebenlistb ; Bysani Chandrasekara ; c ; 2 ; chandrasekarb@health.missouri.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：TRAF3IP2 ; CIKS ; Act1 ; Atherosclerosis ; Plaque stability ; Collagen
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：252
- 期：Complete
- 页码：153-160
- 全文大小：1323 K
文摘
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TRAF3IP2 gene deletion reduces atherosclerosis in female ApoE−/− mice.
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TRAF3IP2 gene deletion decreases plaque necrotic core size in both genders.
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TRAF3IP2 gene deletion increases features of plaque stability.
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TRAF3IP2 gene deletion inhibits aortic proinflammatory and extracellular matrix genes.
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TRAF3IP2 could be a potential therapeutic target in atherosclerotic vascular diseases.