Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone + salt-induced cardiac fibrosis in vivo
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- 作者：Srinivas Mummidia ; Nitin A. Dasb ; Andrea J. Carpenterb ; Hemanthkumar Kandikattuc ; Maike Krenzd ; Ulrich Siebenliste ; Anthony J. Valentea ; Bysani Chandrasekarc ; f ; chandrasekarb@health.missouri.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aldosterone ; Metformin ; AMPK activators ; TRAF3IP2 ; Cardiac fibrosis
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：95-102
- 全文大小：1306 K
文摘
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Aldosterone induces activation, proliferation and migration of cardiac fibroblasts via TRAF3IP2.
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Aldosterone stimulates collagen expression and secretion in vitro.
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Aldosterone + salt enhances TRAF3IP2-dependent inflammatory cytokine expression in wild type mouse hearts.
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Aldosterone + salt enhances collagen expression and deposition in wild type mouse hearts.
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Metformin exerts anti-inflammatory, anti-hypertrophic and anti-fibrotic effects.