TRAF3IP2 mediates aldosterone/salt-induced cardiac hypertrophy and fibrosis
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- 作者：Siva S.V.P. Sakamuria ; 1 ; Anthony J. Valenteb ; Jalahalli M. Siddeshaa ; 2 ; Patrice Delafontainea ; 3 ; Ulrich Siebenlistc ; Jason D. Gardnerd ; Chandrasekar Bysania ; 3 ; 4 ; chandrasekarb@health.missouri.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：RAAS ; Aldosterone ; TRAF3IP2 ; CIKS ; Act1 ; Cardiac fibrosis ; Cardiac hypertrophy
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：5 July 2016
- 年：2016
- 卷：429
- 期：Complete
- 页码：84-92
- 全文大小：1971 K
文摘
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Aldosterone induces cardiac TRAF3IP2 expression in WT mice.
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TRAF3IP2-null mice are resistant to aldosterone-induced cardiac hypertrophy.
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TRAF3IP2-null mice are resistant to aldosterone-induced cardiac fibrosis.
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TRAF3IP2 mediates aldosterone-induced pro-hypertrophic gene expression.
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TRAF3IP2 mediates aldosterone-induced proinflammatory and fibrotic gene expression.