Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex
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- 作者：Yuxuan Miao1 ; 5 ; ymiao@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author ; Jianxuan Wu2 ; Soman N. Abraham1 ; 2 ; 3 ; 4
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：45
- 期：1
- 页码：94-105
- 全文大小：3348 K
文摘
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TRIF- and TRAM-mediated compartmental TLR4 signaling initiates expulsion of UPEC
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Exocyst complex is mobilized by TLR4 signaling to directly export intracellular UPEC
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TRAF3 interacts with RalGDS, which activates exocyst complex assembly via RalB GTPase
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Accurate expulsion depends on RalGDS sensing K33-linked ubiquitination on TRAF3