The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking
刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1367-1374
全文大小:1753 K
卷排序:482
文摘
NEGR1 interacts with NPC2, a key player in intracellular cholesterol trafficking. NEGR1 co-localizes with NPC2 in the late endosomes and increases NPC2 stability. NEGR1 overexpression relieved cholesterol accumulation in endosomal compartments. These findings provide the first insight into the role of NEGR1 in intracellular cholesterol homeostasis and human obesity.