Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes
The endocannabinoid system is involved in regulation of voluntary locomotion. We studied 4 replicate lines of high runner (HR) mice bred for wheel exercise. Blood was collected during peak running on night 6 of wheel access. 2-AG and/or AEA levels differed between the sexes and between HR and control lines. Levels were also affected by wheel access (training effect) and acutely by activity.