Influence of components of tumour microenvironment on the response of HCT-116 colorectal cancer to the ruthenium-based drug NAMI-A

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• 作者：Alberta Bergamo^a ; ^{a.bergamo@callerio.org} ; Chiara Pelillo^a ; Angela Chambery^b ; Gianni Sava^a ; ^c
• 关键词：Colorectal cancer ; Microenvironment ; Ruthenium ; Metastasis
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：90-97
• 全文大小：1614 K
• 卷排序：168

文摘

Healthy epithelial colon cells influence the growth of colorectal cancer cells. Soluble factors from the healthy microenvironment cells modulate gene expression. The drug NAMI-A is imidazolium trans-imidazoledimethylsulfoxidetetrachloro ruthenate. NAMI-A counteracts the effects of the microenvironment on gene expression. Gene expression control by NAMI-A supports its inhibition of tumour cell migration.