Upregulation of the double-stranded RNA binding protein DGCR8 in invasive ductal breast carcinoma
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- 作者：Hedieh Fardmanesha ; Mohammad Shekaria ; mshekari_ch@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Abolfazl Movafaghb ; Shohreh Alizadeh Sharghc ; Ali Akbar Poursadegh Zonouzia ; Samira Shakerizadeha ; Ahmad Poursadegh Zonouzid ; Asghar Hosseinzadehe
- 关键词：miRNA ; MicroRNA ; DGCR8 ; DiGeorge Syndrome Critical Region 8 ; IDC ; Invasive Ductal Breast Carcinoma ; TRBP ; Transactivating Response RNA Binding Protein ; dsRBDs ; double-stranded RNA Binding Domains ; cDNA ; complementary DNA ; PCR ; Polymerase Chain Reaction ; mRNA ; Messenger RNA ; 5&prime ; UTR ; 5&prime ; Untranslated Region ; HER2 ; Human Epidermal Growth Factor Receptor 2 ; CEA ; Carcinoembryonic Antigen ; BMI ; Body Mass Index
- 刊名：Gene
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：581
- 期：2
- 页码：146-151
- 全文大小：537 K
文摘
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DGCR8 is a cofactor for Drosha in microRNA maturing microprocessor complex.
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Dysregulation of DGCR8 expression has been reported is in several malignancies.
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We evaluated DGCR8 mRNA expression levels in IDC specimens.
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DGCR8 overexpressed in cancerous tissues compared to tumor-adjacent normal ones.